Implantation failure patient

Infertility testing and treatment

Director, Kaoru Miyazaki

Graduated from Keio University School of Medicine in 2004. In 2013 he completed the Graduate School of Medicine, Keio University. He was a physician as well as an assistant professor of obstetrics and gynecology at Tokyo Dental College Ichikawa General Hospital, and an assistant professor of obstetrics and gynecology at Keio University. He was a research assistant professor of obstetrics and gynecology at Northwestern University in Chicago from 2017-2018. In 2018, he started as a part-time doctor at Hara Medical Clinic, and since 2020 he has been director of the clinic. He is a board certified specialist and instructor with the Japan Society of Obstetrics and Gynecology, a reproductive medicine specialist, a regenerative medicine certified doctor, a board certified member of The Japan Society for Menopause and Women’s Health, and an endocrinologist with the Japan Endocrine Society.

Efficacy of outpatient implantation failure.

If a low level of beta-hCG is found in the blood when determining pregnancy after IVF, it should not be considered as a failure of IVF, but rather as a miscarriage before implantation or a very early miscarriage, in which there was implantation failure (disorder). The definition of implantation failure is the inability to establish a pregnancy even after multiple transfers of morphologically and functionally good embryos (good grade embryos). Implantation is the result of a complex and harmonious interaction between the embryo and the endometrium. Therefore, elucidating the cause of the problem is not an easy task. However, it is important to perform the main tests for implantation failure in order to prevent the next IVF attempt from failing. Please make an appointment at our outpatient clinic if you are having trouble conceiving due to implantation failure or if you would like to have an implantation test before undergoing IVF.

Implantation Failure Outpatient Testing Flow.

For implantation failure outpatients, we will start with the necessary tests to investigate causes of failure. Even if the test has already been performed at another clinic or at our clinic, we will perform it again if we deem it necessary, as one test alone may not be enough to detect the problem.)

At your initial appointment
Detailed examination and analysis of treatment history, medical questionnaire, internal examination (ultrasound)
Testing item
  • ・Infectious disease (Blood sampling)
  • ・Endocrine examination
  • ・Self-immunization anomaly
  • ・Blood coagulation test
  • ・Examination of uterine morphology (ultrasonography, hysteroscopy, hysterosalpingogram)
  • ・Matrimonial chromosome test
Summary of test results
After the examination, we will explain the treatment plan based on the results.
Treatment example
  • ・Endometrium-Improving Drugs
  • ・Anticoagulant therapy
  • ・Dilation and curettage
  • ・Transvaginal Laparoscopy

About testing

In principle, the cost is at your own expense

It may be covered by insurance only if a related disease is founded.
[Set inspection cost] ¥28,600(Tax included)

Cause Detail Test Items cost Contents of set inspection
Immunological Testing Antiphospholipid- antibodies.
Antibody reaction to injury, blood clots easily
Anti-cardiolipin antibody IgG ¥3,141
Anti-cardiolipin antibody IgM ¥4,400
Anti CL・β2GPⅠantibody ¥3,121
lupus anticoagulant ¥3,950
Anti-PE antibody, IgG ¥8,800 -
Autoimmune test antinuclear antibody ¥1,251
Test for vitamin D levels in the blood Vitamin D level ¥4,950
Test for zinc levels in the blood Zinc level ¥1,100
Coagulation system test Blood clots more easily, reducing the blood supply to the embryo. APTT -
PT ¥251
Coagulation of the factor ¥3,771
Protein S activity ¥2,131
Protein C activity ¥3,260
Metabolic test Diabetes, suspected PCO HbA1c ¥681
Thyroid test Abnormal thyroid function TSH、FT4 ¥4,202 -
MMorphology of the Uterus Direct examination of the uterine cavity. Hysteroscope ¥19,800 -
Contrast-enhanced examination of the uterine cavity. Hysterosalpingography ¥8,360 -
Endocrine test luteal insufficiency P4 ¥2,420 -
Chromosome analysis Chromosomal abnormality
Abnormality rate, male 3%, female 4%.
Couple chromosome
(one person)
¥33,000 -
Immunological tests Test to determine the ratio of Th1 and Th2 cells. Th1/Th2 ¥31,900 -

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